O mea tau vaila'au Bromazolam CAS 71368-80-4
Fa'amatalaga Autu
fua mole: C17H13BrN4
- Liu liusuavai: 272.0-275 ℃
- Mea fa'apuna: 519.8±60.0 °C(Va'ai)
- mafiafia: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40(Va'ai)
- Fuafuaga mole: C17H13BrN4
- Molecular Weight: 353.21600
- Misasa'o: 352.03200
- PSA: 43.07000
- LogP: 3.12480
Fa'aoga
Bromazolam o loʻo faʻavasegaina o se tala fou benzodiazepine lea na muamua faʻapipiʻiina i le 1976, ae e leʻi faʻatauina.Mulimuli ane na faʻatau atu e avea o se vailaʻau faʻataʻitaʻi, muamua na faʻamaonia manino e le EMCDDA i Suetena i le 2016. O le bromo nai lo le chloro analogue o alprazolam, ma e tutusa aʻafiaga ma faʻalavelave faʻalavelave.O le Bromazolam e foliga tutusa ma benzodiazepines masani, e aofia ai le alprazolam (suia le chlorine i le bromine) ma le bromazepam (faʻaopoopoina o le triazole mama).Alprazolam ma bromazepam o mea Faʻatonu IV i le Iunaite Setete;bromazolam e leʻo faʻatulagaina manino.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine o loʻo faʻaaogaina e suʻesuʻe ai le gaioiga antianxiety, antidepressant ma psychotropics mo le fatugalemu o le tino.
Metotia Sauniuniga
Na togafitia i latou i le pHLS9 (2 mg protein / mL), 25 μg / mL Alamethicin (UGT reaction mixture B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, ma le 0.6 mM i le 37 ° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase ma 0.1 mM acetyl-CoA.Ona, 2.5 mM UDP-glucuronic acid (UGT reaction mixture solution A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, ma le 50 μM clobromazolam poʻo Bromazolam na faʻaopoopoina.
Tulaga Tali:50 μM Bromazolam mo le 360min ile 37°C
Talosaga:Bromazolam metabolites safaailoainai le pHLS9 incubation.