CAS: 959610-44-7 Myristoyl hexapeptide-4 Sympide 230 Myristoyl hexapeptide-4

O le Neuropituitrin o se vasoconstrictor ma antidiuretic, lea e mafai ona faʻaaogaina mo hemostasis postpartum, faʻalauteleina le faʻamaʻiina o le uterine ma le le atoatoa o le faapau pepe.E fa'aaogaina fo'i mo le togafitia o le esophageal ma le gastric fundus varices rupture bleeding, diabetes insipidus ma isi.Metotia Gaosia Ave'ese o le pa'u o lau pito i tua O lau pito i tua na fa'amago i se masini fa'agogo ma le phosphorus pentoxide (susū e itiiti ifo i le 3%) ma fa'apalapala ma fa'apolopolo e maua ai le pa'u laula'au pito i tua.Ona faaopoopo lea o le 90% acetone (3-6 taimi), faʻafefe i le 25 ℃ mo le 4h ma tuʻu i le po.O lea e toe fai togafitiga 2-3 taimi, ave sina vaega itiiti o le acetone vai ma sina vaega itiiti o vai faʻafefe e le toe faʻafefe.Ona togafitia lea i le eter (3 taimi le aofaʻi) mo le 1 taimi, faʻamama, faʻafefe faʻanatura eter e mago, maua pe a uma lau paʻu.Acetone, ether togafitiga o le aveesea o mea maualalo molecular ma lipids, ina ia mautinoa le manino.Porcine neurohypophysial [P2O5]→ crude hypophysial powder [acetone, ether]→ [25℃,4h] Faʻamamaina o le paʻu o le hypophysial O le paʻu o le hypophysial na faʻaluaina e ala i le faʻaopopoina o le 0.25% acetic acid, o le taimi muamua faʻaopoopo 5 taimi le aofaʻi, o le taimi lona lua fa'aopoopo 2 taimi le aofa'i, fa'aoso i le 50 ℃ mo le 15min, filtration.Ina ua mae'a le su'ega e lua, ona tu'u fa'atasi lea o le filtrate ma fa'avevela i le saoasaoa o le tusi o vaila'au i le 100 ℃ mo le 15min.Ona faaopoopo lea o le 0.5% trichloro-tert-butanol (1:1 volume ratio, activated carbon treatment pe'ā manaʻomia) aʻo vevela.O le filtrate sa faamalūina i se saoasaoa vave i lalo ole 30 ℃.O le acetic acid extract o loʻo i ai polotini le aoga ma enzymes self-hydrolyzing, lea e mafai ona faʻamaopoopoina ma faʻaumatia e ala i le faʻavevelaina (faʻaaliga: o le oxytocin titer o le oxytocin e faigofie ona paʻu i lalo o le alkaline poʻo le malosi malosi. Stable i mea vaivai e pei o le pH3-4, ma ausa sterilization i le 100 ℃ mo le 30min po o le vevela vevela sterilization foi mautu).Fa'amama lau pa'u pa'u [0.25% acetic acid]→[50℃,15min] filtrate [0.5% trichloro-tert-butanol]→ [pu'aisa, fa'amama] fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;pe'a fa'amama lau pa'u;O le pH na faʻafetaui i le 3.5 faʻatasi ai ma le acetic acid glacial, faʻamama e ala i luga o le faʻafefete faʻafefete, faʻamaufaʻailoga, ma faʻamaʻi i le ausa i le 100 ℃ mo le afa itula e maua ai le tui pito i tua.Afterleaf powder [su'ega titer]→[pH3.5] Afterleaf tui [filtration, sterilization]→ afterleaf tui oloa mae'a tui.